Researchers from the University of Wisconsin-Madison have found those with a mutation of the TEK gene are at a higher risk for developing newborn or later-onset forms of glaucoma.
For the study, researchers recruited families with at least one child with primary congenital glaucoma (PCG), and reportedly identified 10 families with mutations in the TEK gene. All of the mutations identified in these families reportedly resulted in disturbance of the cellular signaling pathway necessary for Schlemm’s canal development.
The study, “Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity,” was published in The Journal of Clinical Investigation.
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Source: University of Wisconsin-Madison School of Medicine & Public Health