Researchers at the American Society of Microbiology (ASM) Microbe research meeting presented new information on how common bacterial contaminant on contact lenses and cases can cause the formation of large bubble-like membrane structures on human ocular cells, leading to complications and inflammation.
The researchers reportedly observed bacteria including Proteus mirabilis and Serratia marcescens that cause eye and other infections, induce major morphological changes in the surface of epithelial and other cell types. Using molecular genetics, the scientists found a regulatory protein that they are calling GumB and a secreted protein called ShlA are responsible for the membrane bubbles — or blebs — to form. Researchers believe their findings may help pave the way for new therapies that alleviate inflammation.
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Source: American Society of Microbiology